Position Summary

This position offers the opportunity to work in a multidisciplinary team on cutting-edge technologies at the intersection of disease relevant cell biology, genome engineering, massively parallel high-content single-cell screening and machine learning. This role will spearhead the team's efforts in designing and developing novel functional high-throughput CRISPR screening techniques and assays, as well as being part of the team’s effort to perform novel single-cell RNA sequencing applications. This role will require close collaboration with the wet-lab R&D team for data-driven refinement of experimental designs and new method development. The successful candidate will be an excellent team player and communicator who can thrive in a fast-paced startup environment.

Key Responsibilities

• Lead engineering and characterization of novel editing systems focused on high-throughput experimentation
• Design and execute pooled and single-cell screens using existing tools as well as developing bespoke tools for state-of-the-art single-cell applications
• Collaborate closely with the wet-lab R&D team on method development and experimental design to support data interpretation and target prioritization
• Collaborate closely with the computational data analysis team on method experimental design readout to support data interpretation and target prioritization
• Maintain extensive knowledge of the literature and best practices related to functional readouts, screening, and experimental design
• Effectively analyze and present data, and communicate research plans and timelines to the team
• Maintain detailed, well-organized, and timely documentation of experiments and data
• Live Neptune Bio’s core values of being biologically inspired, being honest and rigorous about our research, and fostering a supportive environment.

Qualification and Education Requirements

You must have:

• PhD degree in Biology, Biomedical Engineering, or related fields with training in high-throughput screening and single-cell genomics
• 2+ years of biotech or industry experience
• Strong track record in CRISPR genome engineering, pooled CRISPR screening, CRIPSR screening method development or single-cell functional genomics
• Deep knowledge in molecular biology, screen design, sequencing assay design with several years of academic or industry experience
• Experience with viral infection including lentivirus preparation
• Mammalian cell culture experience, strongly preferring IPSCs or organoid models
• Strong problem-solving ability and aptitude for innovation
• Ability to adjust rapidly to shifting priorities and deliver high-quality, detail-oriented results in a timely manner
• High degree of teamwork and collaborative attitude are essential
• Ability to work independently

Additional preferred experience includes:

• Strong translation biology background
• Experience with fluorescence activated cell sorting (FACS)
• Willingness to quickly discover and learn new methods and approaches

At Neptune Bio, we are committed to matching our new hires to the level that best fits with the experience they bring with them. For this job, the levels we will hire at are:

• Scientist II: $120,000-$140,000
• Senior Scientist: $140,000-$160,000