Position Summary

This position will work as part of a multidisciplinary team, leading the effort to validate novel drug targets discovered through the Neptune platform, in validated and translational In vitro models. The ideal candidate should have experience with a diverse range of In vitro models and testing methods across different therapeutic areas while also having the curiosity and appetite to learn, including developing novel models in new therapeutic areas. The successful candidate will also be an excellent team player and communicator who can thrive in a fast-paced startup environment.

Key Responsibilities

• Develop, optimize, and validate cellular and biochemical assays to support target identification, confirm mechanism of action and enable lead optimization.
• Design, execute, and analyze in vitro experiments to evaluate pharmacological properties of potential therapeutic leads across modalities including small molecules, biologics, genetic and cell-based therapies
• Perform cell culture, including primary cell isolation and maintenance of cell lines including 3D/organoid models, to support diverse project needs
• Analyze,interpret and communicate results and import of experimental data to inform project strategies and drive decision-making
• Author detailed experimental protocols, technical reports, present findings at internal meetings and external scientific conferences

Qualification and Education Requirements

You must have:

• PhD in Cell Biology, Pharmacology, Molecular Biology, or related field with 3+ of relevant industry experience
• Proven track record of developing and running translational In vitro models (e.g., viability, signaling, and functional assays) as a part of comprehensive pharmacological profiling
• Proficiency in molecular and cellular biology techniques, including but not limited to flow cytometry
• Knowledge of pharmacological principles (e.g., potency, efficacy, and kinetics) and computational tools as applied to drug discovery and development (e.g., screening methodology using single-cell and bulk data, dose-response and PK/PD analysis, etc.)
• Strong problem-solving ability and aptitude for innovation
• Adaptable/Flexible and able to prioritize and work across multiple projects in parallel while delivering high-quality, detail-oriented results in a timely manner
• High degree of teamwork and collaborative attitude are essential
• Ability to work independently

Additional preferred experience includes:

• Experience with developing 3D cultures or organoid models
• Previous experience managing both internal work and outsourced work at CROs

Experience with high-throughput screening and CRISPR is desired, but not required